Recombinant GABBR1 antibody

Catalog No. ABIN7828218

The Rabbit Monoclonal anti-GABBR1 antibody (Clone A650) (ABIN7828218) specifically detects GABBR1 in WB and IHC. The antibody is reactive with Rat and Mouse samples.

Quick Overview for Recombinant GABBR1 antibody (ABIN7828218)

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Antibody Type: Recombinant Antibody

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GABBR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A650

Product Details anti-GABBR1 Antibody

Purpose: Recombinant GABA B Receptor 1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human GABA B Receptor 1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:200-1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for GABBR1

Target: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Alternative Name: GABA B Receptor 1

Background: GABBR,GABABR,GABBR1,GABABR1,GABBR1-3,GB1,GPRC3A,GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site. GABA(B)R1 has two isoforms: GABA(B)R1a and GABA(B)R1b. GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein. G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 108 kDa

Observed MW: 108 kDa

UniProt: Q9UBS5

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process