Recombinant Gelsolin antibody

Catalog No. ABIN7828221

The Rabbit Monoclonal anti-Gelsolin antibody (Clone A612) (ABIN7828221) specifically detects Gelsolin in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant Gelsolin antibody (ABIN7828221)

Target: Gelsolin (GSN)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Gelsolin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A612

Product Details anti-Gelsolin Antibody

Purpose: Recombinant Gelsolin Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Gelsolin fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:100-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Gelsolin

Target: Gelsolin (GSN)

Alternative Name: Gelsolin

Background: DKFZp313L,GSN,ADF,AGEL,gelsolin,Actin depolymerizing factor,DKFZp313L0718,Brevin,GELS,Actin-depolymerizing factor,Actin-depolymerizing factor,ADF,AGEL,Brevin,GELS,GSN,Gelsolin also named as actin-depolymerizing factor, ADF, AGEL or Brevin, is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin. Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner. Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling. Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation. In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 85 kDa

Observed MW: 82 kDa The actual band is not consistent with the expectation.

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy