Recombinant GPX4 antibody

Catalog No. ABIN7828231

This Rabbit Monoclonal antibody specifically detects GPX4 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant GPX4 antibody (ABIN7828231)

Target: GPX4 (Glutathione Peroxidase 4 (GPX4))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GPX4 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A587

Product Details anti-GPX4 Antibody

Purpose: Recombinant Glutathione Peroxidase 4 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Glutathione Peroxidase 4 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for GPX4

Target: GPX4 (Glutathione Peroxidase 4 (GPX4))

Alternative Name: Glutathione Peroxidase 4

Background: Glutathione peroxidase,GSHPx,GPx,GPX4,GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx,glutathione peroxidase 4,glutathione peroxidase 4,GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx,The selenoprotein glutathione peroxidase 4 (GPX4) is a master regulator of ferroptosis, a form of programmed cell death induced by iron-dependent lipid peroxidation. GPX4 converts lipid hydroperoxides to non-toxic lipid alcohols, therefore preventing ferroptosis. Research studies show that selenium enhances GPX4 expression and inhibits ferroptotic death to protect neurons. In addition, some therapy-resistant cancer cells depend on GPX4 to survive. Loss of GPX4 leads to ferroptosis and thus prevents tumor relapse in mice. Furthermore, redox homeostasis mediated by GPX4 is essential for activation of the cytosolic DNA-sensing cGAS-STING pathway and initiation of the subsequent innate immune response. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 22 kDa

Observed MW: 22 kDa

UniProt: P36969