Recombinant HSPE1 antibody

Catalog No. ABIN7828249

This Rabbit Monoclonal antibody specifically detects HSPE1 in WB, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant HSPE1 antibody (ABIN7828249)

Target: HSPE1 (Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HSPE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A193

Product Details anti-HSPE1 Antibody

Purpose: Recombinant Cpn10 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Cpn10 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:200-1:1000,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for HSPE1

Target: HSPE1 (Heat Shock 10kDa Protein 1 (Chaperonin 10) (HSPE1))

Alternative Name: Cpn10

Background: CPN,HSP,HSPE,HSPE1,CPN10,EPF,GROES,HSP10,10 kDa chaperonin,10 kDa heat shock protein,10 kDa heat shock protein mitochondrial,CH10,Chaperonin 10,Chaperonin 10 homolog,cpn10 homolog,Early pregnancy factor,Early-pregnancy factor,GroES homolog,Heat shock 10kD protein 1 chaperonin 10,Heat shock 10 kDa protein 1,Heat shock 10 kDa protein 1 chaperonin 10,Heat shock protein family E (Hsp10) member,Heat-shock 10-kD protein,mitochondrial,Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 11 kDa

Observed MW: 11 kDa

UniProt: P61604

Pathways: Positive Regulation of Endopeptidase Activity