Recombinant HOXB13 antibody

Catalog No. ABIN7828292

The Rabbit Monoclonal anti-HOXB13 antibody is suitable to detect HOXB13 in samples from Human. It has been validated for WB.

Quick Overview for Recombinant HOXB13 antibody (ABIN7828292)

Target: HOXB13 (Homeobox B13 (HOXB13))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HOXB13 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A632

Product Details anti-HOXB13 Antibody

Purpose: Recombinant HOXB13 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human HOXB13 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000-1:5000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for HOXB13

Target: HOXB13 (Homeobox B13 (HOXB13))

Alternative Name: HOXB13

Background: HXB,Homeobox B,Homeo box B,Homeobox protein HoxB,Homeobox protein Hox B,Homeobox protein Hox-B,HOX B,HOXB13,PSGD,Homeo box B13,Homeobox B13,Homeobox protein Hox B13,Homeobox protein HoxB13,Homeobox protein Hox-B13,HOX B13,HOXB 13,HXB13,PSGD protein,HOXB13 is a member of the HOXB cluster which, along with the HOXA, HOXC, and HOXD clusters, governs embryonic patterning along the cranio-caudal axis. HOXB13 plays a key role in the development of the ventral prostate, where it is expressed highly from the embryonic stage through adulthood. Research studies have shown that both overexpression and RNA interference can inhibit the growth of prostate cancer cells. HOXB13 can function as a tumor suppressor by negatively regulating growth through repression of TCF4 and androgen receptor (AR) signaling. However, HOXB13 has also been shown to be overexpressed in more invasive prostate cancers, breast and ovarian cancers, and hepatocellular carcinomas. A common germline mutation G84E in the HOXB13 protein has recently been found to be associated with significant increased risk of prostate cancer. Currently, HOXB13 is being evaluated as a marker for metastatic lesions of prostate origin. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 31 kDa

Observed MW: 31 kDa

UniProt: Q92826