Recombinant INPPL1 antibody

Catalog No. ABIN7828310

The Rabbit Monoclonal anti-INPPL1 antibody is suitable to detect INPPL1 in samples from Human. It has been validated for WB, IHC and IF.

Quick Overview for Recombinant INPPL1 antibody (ABIN7828310)

Target: INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This INPPL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A749

Product Details anti-INPPL1 Antibody

Purpose: Recombinant SHIP-2 Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:100,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for INPPL1

Target: INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))

Alternative Name: SHIP-2

Background: SHIP,INPPL,INPPL1,OPSMD,SHIP2,5 trisphosphate 5 phosphatase 2,51C protein,5-trisphosphate 5-phosphatase 2,EC 3.1.3.n1,inositol polyphosphate phosphatase like 1,Inositol polyphosphate phosphatase like protein 1,Inositol polyphosphate phosphatase-like protein 1,INPPL-1,Phosphatidylinositol 3,Protein 51C,SH2 domain containing inositol 5' phosphatase 2,SH2 domain-containing inositol 5''-phosphatase 2,SH2 domain-containing inositol phosphatase 2,SHIP-2,SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif, followed by tyrosine phosphorylation on the NPXY motif. The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1. Its effect on calcium flux, cell survival, growth, cell cycle arrest, and apoptosis is mediated through the PI3K and Akt pathways. Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function.SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta.SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes. Tyr1135 is phosphorylated in human cancer cells. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 139 kDa

Observed MW: 140 kDa The actual band is not consistent with the expectation.

UniProt: O15357

Pathways: Platelet-derived growth Factor Receptor Signaling