Recombinant MYCN antibody

Catalog No. ABIN7828415

The Rabbit Monoclonal anti-MYCN antibody is suitable to detect MYCN in samples from Human. It has been validated for WB.

Quick Overview for Recombinant MYCN antibody (ABIN7828415)

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MYCN antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A754

Product Details anti-MYCN Antibody

Purpose: Recombinant N-Myc Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:50000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for MYCN

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Alternative Name: N-Myc

Background: BHLHe,MODED,N-myc,NMYC,ODED,bHLHe37,MYCN,Class E basic helix-loop-helix protein 37,N myc,N myc proto oncogene protein,Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene,Neuroblastoma MYC oncogene,NMYC proto oncogene protein,N-myc proto-oncogene protein,Oncogene NMYC,pp65/67,V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog,v myc avian myelocytomatosis viral related oncogene neuroblastoma derived,v myc myelocytomatosis viral related oncogene neuroblastoma derived,Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior, including proliferation, differentiation, and apoptosis. These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription. Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families. The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior. The Mad family consists of four related proteins, Mad1, Mad2 (Mxi1), Mad3, and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes, such as proliferation, transformation, and prevention of apoptosis by inhibiting transcription.In humans the Myc family consists of 5 genes: c-Myc, N Myc, L-Myc, R-Myc, and B-Myc. While c-Myc is expressed in many proliferating cells, N-Myc expression is very restricted, with highest levels in during embryonic development and then in the adult during B-cell development. These expression patterns and results from targeted deletion of N-Myc suggest that N-Myc plays an important role in tissue development and differentiation. In addition, amplification or overexpression of N-Myc has been found in human neuroblastomas and is associated with rapid progression and poor prognosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 50 kDa

Observed MW: 62 kDa The actual band is not consistent with the expectation.

UniProt: P04198