Recombinant PAX8 antibody

Catalog No. ABIN7828439

The Rabbit Monoclonal anti-PAX8 antibody is suitable to detect PAX8 in samples from Human, Mouse and Rat. It has been validated for IHC and IF.

Quick Overview for Recombinant PAX8 antibody (ABIN7828439)

Target: PAX8 (Paired Box 8 (PAX8))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PAX8 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: A323

Product Details anti-PAX8 Antibody

Purpose: Recombinant PAX8 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human PAX8 fragment

Isotype: IgG, kappa

Application Details

Application Notes: IHC 1:50-1:100,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for PAX8

Target: PAX8 (Paired Box 8 (PAX8))

Alternative Name: PAX8

Background: Paired box,Paired box gene,Paired domain gene,paired box homeotic gene,PAX,PAX8,OTTHUMP00000158659,OTTHUMP00000158660,OTTHUMP00000203723,OTTHUMP00000203724,Paired box 8,Paired box gene 8,paired box homeotic gene 8,Paired box protein Pax 8,Paired box protein Pax-8,Paired domain gene 8,PAX 8,PAX8 is one of nine transcription factors within the PAX gene family. It has been observed to be expressed during embryonic development however expression attenuates after development in all but a few tissues. Research has indicated that over-expression of PAX proteins in general are not an initiating event in tumorgenesis however they may facilitate malignant development. PAX8 is expressed in 80-96 % of all High-grade serous carcinomas (HGSC) and is commonly used as a marker for the disease. In addition PAX8 has become a useful biomarker for differentiating between mullerian mucinous and non-mullerian tumors. PAX8 has also been associated with neoplasms in the kidney and thyroid. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: Q06710

Pathways: Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation