Recombinant PLAG1 antibody

Catalog No. ABIN7828465

This Rabbit Monoclonal antibody specifically detects PLAG1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant PLAG1 antibody (ABIN7828465)

Target: PLAG1 (Pleiomorphic Adenoma Gene 1 (PLAG1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PLAG1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A660

Product Details anti-PLAG1 Antibody

Purpose: Recombinant PLAG1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human PLAG1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:5000-1:10000,IHC 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for PLAG1

Target: PLAG1 (Pleiomorphic Adenoma Gene 1 (PLAG1))

Alternative Name: PLAG1

Background: ZNF,Zinc finger protein PLAG,Pleiomorphic adenoma gene,FGFR1/PLAG1 fusion variant,PLAG,COL1A2/PLAG1 fusion,FGFR1/PLAG1 fusion variant 3,Pleiomorphic adenoma gene 1,Pleiomorphic adenoma gene 1 protein,PSA,SGPA,Zinc finger protein PLAG1,ZNF912,PLAG1,PSA,SGPA,Pleiomorphic adenoma gene 1 protein (PLAG1) is a transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. When PLAG1 overexpression in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. PLAG1 ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. PLAG1 overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. PLAG1 cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 56 kDa

Observed MW: 56 kDa

UniProt: Q6DJT9