Recombinant SIRT6 antibody

Catalog No. ABIN7828568

The Rabbit Monoclonal anti-SIRT6 antibody is suitable to detect SIRT6 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for Recombinant SIRT6 antibody (ABIN7828568)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A547

Product Details anti-SIRT6 Antibody

Purpose: Recombinant SIRT6 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human SIRT6 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background: SIRT,SIR2L,sirtuin,SIR2L6,SIRT6,sirtuin 6,SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 39 kDa

Observed MW: 42 kDa The actual band is not consistent with the expectation.

UniProt: Q8N6T7