Recombinant SV2A antibody

Catalog No. ABIN7828606

This Rabbit Monoclonal antibody specifically detects SV2A in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant SV2A antibody (ABIN7828606)

Target: SV2A (Synaptic Vesicle Glycoprotein 2A (SV2A))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SV2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A710

Product Details anti-SV2A Antibody

Purpose: Recombinant SV2A Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:1000,IHC 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for SV2A

Target: SV2A (Synaptic Vesicle Glycoprotein 2A (SV2A))

Alternative Name: SV2A

Background: KIAA,PSEC,SV2,SV2A,KIAA0736,PSEC0174,SV2s are a family of synaptic vesicle proteins expressed in both neurons and endocrine cells. SV2s function in the regulation of synaptic vesicle traffic, cytoplasmic Ca2+ levels in the nerve terminal during repetitive stimulation and the facilitation of synaptic transmission. There are three isoforms of SV2: SV2A, SV2B and SV2C. Each of these isoforms are structured similarly but expressed varyingly. SV2C, a minor isoform of SV2, expressed in a small subset of neurons located within the basal forebrain, midbrain and brainstem. SV2B, a major isoform of SV2 is expressed more abundantly, although rarely without the coexpression of SV2A. SV2A, the other major isoform of SV2 is the most widely expressed. SV2A is located in the presynaptic nerve terminals of almost every neuron throughout the nervous system. In addition, it is also located in most neuroendocrine secretory granules. SV2A has been identified as a critical protein for proper function of the central nervous system and has been linked to the physiopathology of epilepsy. In addition to the epileptic affects of this protein, mutations in it have also been seen to result in schizophrenia. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 83 kDa

Observed MW: 100 kDa The actual band is not consistent with the expectation.

UniProt: Q7L0J3