Recombinant TBL1XR1 antibody

Catalog No. ABIN7828633

This Rabbit Monoclonal antibody specifically detects TBL1XR1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant TBL1XR1 antibody (ABIN7828633)

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TBL1XR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A640

Product Details anti-TBL1XR1 Antibody

Purpose: Recombinant TBLR1/TBL1XR1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human TBLR1/TBL1XR1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:2000-1:5000,IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for TBL1XR1

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Alternative Name: TBLR1/TBL1XR1

Background: MRD,IRA,TBLR,TBL1XR,TBL1XR1,C21,DC42,IRA1,MRD41,TBLR1,TBL1-related protein 1 (TBLR1/TBL1XR1) and Transducing β-like protein 1 (TBL1X/TBL1) were originally identified as subunits of the co-repressor silencing mediator for retinoic and thyroid hormone receptor (SMRT) and nuclear receptor co-repressor (NCoR) complexes. These two factors are required for the exchange of co-repressor complexes for co-activators by acting as adaptors to recruit the ubiquitin/proteasome machinery that degrades the co-repressor proteins during ligand mediated activation of transcription. Co-factor exchange driven by TBLR1/TBL1XR1 and TBL1X/TBL1 appears to be the mechanism by which c-Jun and NF-κB mediated transcription is activated and is therefore likely to be the mechanism employed by other signal-dependent transcription factors as well. In addition, both TBLR1/TBL1XR1 and TBL1X/TBL1 have essential roles in regulating the Wnt-signaling pathway by recruiting β-catenin to Wnt target genes to activate transcription. Depletion of TBLR1/TBL1XR1 significantly inhibited Wnt-beta-catenin- induced gene expression and oncogenic growth in vitro and in vivo. Research studies have shown that upregulation of TBLR1/TBL1XR1 is observed in a variety of solid tumors, and is correlated with advanced tumor stage, metastasis and poor prognosis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 56 kDa

Observed MW: 60 kDa The actual band is not consistent with the expectation.

UniProt: Q9BZK7

Pathways: Regulation of Lipid Metabolism by PPARalpha