Granzyme D/B/E/N/G/F/H (AA 151-252) antibody (HRP)

Catalog No. ABIN742359

The HRP-conjugated Rabbit Polyclonal anti-Granzyme D/B/E/N/G/F/H antibody (ABIN742359) specifically detects Granzyme D/B/E/N/G/F/H in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Granzyme D/B/E/N/G/F/H (AA 151-252) antibody (HRP) (ABIN742359)

Target: Granzyme D/B/E/N/G/F/H

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: HRP

Application: Western Blotting (WB), ELISA

Product Details

Binding Specificity: AA 151-252

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Granzyme D/B/E/N/G/F/H

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Granzyme D/B/E/N/G/F/H

Background:

Synonyms: Granzyme D, Granzyme B, Granzyme E, Granzyme N, Granzyme G, Granzyme F, Granzyme H, Cathepsin G-like 2, CCP-X, CCP3, CCP4, CCP5, CGL-2, CSP-C, Ctla-5, Ctla-6, Ctla-7, CTLA1, CTSGL2, Grz d, Grz e, Grz f, Grz g, GZMD, Gzme, Gzmf, Gzmg, GZMH, MCSP-2, MCSP-3, MGC117682, Rnkp7, mast cell proteinase-3-like, Cytotoxic T-lymphocyte proteinase, Granzyme H precursor, Cytotoxic serine protease-C, CSP-C.

Background: protease required for lymphocyte cytotoxic granules to lyse target cells [RGD]. Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.

Gene ID: 2999