STING1 (AA 190-290) antibody

Catalog No. ABIN7859338

The Mouse Monoclonal anti-STING1 antibody (Clone STING1-7433) (ABIN7859338) specifically detects STING1 in IHC and WB. The antibody is reactive with Human samples.

Quick Overview for STING1 (AA 190-290) antibody (ABIN7859338)

Target: STING1

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Clone: STING1-7433

Product Details

Binding Specificity: AA 190-290

Purpose: STING1 / TMEM173 Antibody

Specificity: TMEM17 (transmembrane protein 173) is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa190-290) of human TMEM173 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details

Target: STING1

Background:

Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, MITA, NET23, MPYS, Mitochondrial mediator of IRF3 activation, N terminal methionine proline tyrosine serine plasma membrane tetraspanner, Stimulator of interferon genes protein, Transmembrane protein 173

Cytoplasmic expression in several tissues including cells in respiratory tract|fallopian tube and cells in lymphoid tissues.

Molecular Weight: 37-50kDa

Gene ID: 340061, 379754

UniProt: Q86WV6