Plasma Cell Marker antibody

Catalog No. ABIN7865714

This Mouse Monoclonal antibody specifically detects Plasma Cell Marker in IHC. It exhibits reactivity toward Human.

Quick Overview for Plasma Cell Marker antibody (ABIN7865714)

Target: Plasma Cell Marker

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Clone: EBS-O-231

Product Details

Purpose: anti-Plasma-Cell-Marker mouse monoclonal, EBS-O-231, purified

Cross-Reactivity (Details): not with rat

Purification: affinity chromatography

Immunogen: pancreatic cancer related serum mucin

Isotype: IgG2a kappa

Application Details

Application Notes: Optional[ICC/IF_dilution]: 1:50-1:100 (1-2 μg/mL, microwave treatment in 10 mM citrate buffer pH 6.0 recommended)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: store at 2 - 8 °C

Target Details

Target: Plasma Cell Marker

Alternative Name: Plasma-Cell-Marker

Background: EBS-O-231 recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm, their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Positive control: Human toncil.