ADC antibody (AA 1-448)

Catalog No. ABIN7869374

This Rabbit Polyclonal antibody specifically detects ADC in WB, IHC (p), ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ADC antibody (AA 1-448) (ABIN7869374)

Target: ADC (Arginine Decarboxylase (ADC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Flow Cytometry (FACS)

Product Details anti-ADC Antibody

Binding Specificity: AA 1-448

Purpose: Antizyme inhibitor 2 Antibody / AZIN2 / Arginine decarboxylase

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-L448) was used as the immunogen for the Antizyme inhibitor 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Antizyme inhibitor 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Antizyme inhibitor 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ADC

Target: ADC (Arginine Decarboxylase (ADC))

Alternative Name: Antizyme inhibitor 2

Background: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

UniProt: Q96A70