TIMM8A/DDP antibody (AA 14-97)

Catalog No. ABIN7870659

The Rabbit Polyclonal anti-TIMM8A/DDP antibody is suitable to detect TIMM8A/DDP in samples from Human, Mouse, Rat and Monkey. It has been validated for ELISA, WB, FACS, IHC (p) and IF.

Quick Overview for TIMM8A/DDP antibody (AA 14-97) (ABIN7870659)

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMM8A/DDP antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-TIMM8A/DDP Antibody

Binding Specificity: AA 14-97

Purpose: TIMM8A Antibody

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids A14-D97) was used as the immunogen for the TIMM8A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TIMM8A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TIMM8A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TIMM8A/DDP

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Alternative Name: TIMM8A

Background: Mitochondrial import inner membrane translocase subunit Tim8 A, also known as Deafness-dystonia peptide or protein is an enzyme that in humans is encoded by the TIMM8A gene. This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome, an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: O60220