TMEM255B antibody (AA 196-240)

Catalog No. ABIN7871709

The Rabbit Polyclonal anti-TMEM255B antibody is suitable to detect TMEM255B in samples from Mouse and Rat. It has been validated for ELISA, WB and IHC (p).

Quick Overview for TMEM255B antibody (AA 196-240) (ABIN7871709)

Target: TMEM255B (Transmembrane Protein 255B (TMEM255B))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM255B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TMEM255B Antibody

Binding Specificity: AA 196-240

Purpose: Fam70b Antibody / Tmem255b

Purification: Affinity purified

Immunogen: Recombinant mouse protein (amino acids Q196-L240) was used as the immunogen for the Fam70b antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Fam70b antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Fam70b antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TMEM255B

Target: TMEM255B (Transmembrane Protein 255B (TMEM255B))

Alternative Name: Fam70b

Background: FAM70B (family with sequence similarity 70, member B) is a 326 amino acid membrane protein that belongs to the FAM70 family. The gene that encodes FAM70B maps to human chromosome 13, which contains around 114 million base pairs and encodes roughly 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

UniProt: Q5FW56