LRRC59 antibody (AA 20-307)

Catalog No. ABIN7871860

The Rabbit Polyclonal anti-LRRC59 antibody (ABIN7871860) specifically detects LRRC59 in WB, IHC (p), ELISA, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LRRC59 antibody (AA 20-307) (ABIN7871860)

Target: LRRC59 (Leucine Rich Repeat Containing 59 (LRRC59))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC59 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-LRRC59 Antibody

Binding Specificity: AA 20-307

Purpose: LRRC59 Antibody / Leucine-rich repeat-containing protein 59

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids L20-Q307) was used as the immunogen for the LRRC59 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LRRC59 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LRRC59 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LRRC59

Target: LRRC59 (Leucine Rich Repeat Containing 59 (LRRC59))

Alternative Name: LRRC59

Background: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8 % of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

UniProt: Q96AG4