MYORG/KIAA1161 antibody (AA 207-611)

Catalog No. ABIN7872108

The Rabbit Polyclonal anti-MYORG/KIAA1161 antibody is suitable to detect MYORG/KIAA1161 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB and FACS.

Quick Overview for MYORG/KIAA1161 antibody (AA 207-611) (ABIN7872108)

Target: MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYORG/KIAA1161 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-MYORG/KIAA1161 Antibody

Binding Specificity: AA 207-611

Purpose: MYORG Antibody / Myogenesis-regulating glycosidase

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human MYORG recombinant protein (Position: Q207-R611) was used as the immunogen for the MYORG antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MYORG antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MYORG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MYORG/KIAA1161

Target: MYORG/KIAA1161 (MYORG) (Myogenesis Regulating Glycosidase (MYORG))

Alternative Name: MYORG

Background: MYORG antibody detects Myogenesis-regulating glycosidase, a lysosomal and endoplasmic reticulum-associated enzyme involved in protein processing and neurological function. The UniProt recommended name is Myogenesis-regulating glycosidase (MYORG). This glycosidase is highly conserved and plays a crucial role in the maintenance of glycoprotein homeostasis within neural tissues, particularly astrocytes.

Functionally, MYORG antibody identifies a 714-amino-acid glycosidase belonging to the glycosyl hydrolase family 31. MYORG hydrolyzes terminal sugar residues from oligosaccharides and glycoproteins, participating in lysosomal degradation and protein quality control. It is mainly localized to the endoplasmic reticulum and perinuclear regions, suggesting involvement in post-translational processing rather than extracellular digestion.

The MYORG gene is located on chromosome 9p13.1 and is highly expressed in brain and skeletal muscle. In the central nervous system, MYORG supports astrocyte differentiation and intercellular communication. It is co-regulated with genes controlling lysosomal activity, endoplasmic reticulum homeostasis, and metabolic signaling.

Pathologically, mutations in MYORG cause primary familial brain calcification (PFBC), a neurodegenerative disorder characterized by calcium deposits in basal ganglia and cerebellum. Deficiency in MYORG leads to altered glycosylation and impaired protein turnover in astrocytes. Research using MYORG antibody assists studies of glycoprotein metabolism, lysosomal function, and neurological disease mechanisms.

MYORG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect intracellular glycosidases and neuronal processing enzymes. NSJ Bioreagents provides MYORG antibody reagents optimized for neuroscience, enzymology, and cellular metabolism research.

Structurally, Myogenesis-regulating glycosidase contains a catalytic domain typical of glycosyl hydrolases with conserved acid-base residues, and a C-terminal transmembrane region anchoring it to intracellular membranes. This antibody supports analysis of MYORG's biochemical function and contribution to neurodegenerative disorders.

UniProt: Q6NSJ0

Pathways: Skeletal Muscle Fiber Development