MID1 antibody (AA 226-278)

Catalog No. ABIN7872405

The Rabbit Polyclonal anti-MID1 antibody is suitable to detect MID1 in samples from Human and Mouse. It has been validated for WB, ELISA, IF, IHC (p) and FACS.

Quick Overview for MID1 antibody (AA 226-278) (ABIN7872405)

Target: MID1 (Midline 1 (MID1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MID1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-MID1 Antibody

Binding Specificity: AA 226-278

Purpose: MID1 Antibody

Purification: Affinity purified

Immunogen: Amino acids N226-Q278 from the human protein were used as the immunogen for the MID1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MID1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: Store the MID1 antibody at -20oC.

Target Details for MID1

Target: MID1 (Midline 1 (MID1))

Alternative Name: MID1

Background: Midline-1 is a protein found in humans that is encoded by the MID1 gene. The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities.

UniProt: O15344