NAD-ME antibody (AA 26-584)

Catalog No. ABIN7873011

The Rabbit Polyclonal anti-NAD-ME antibody is suitable to detect NAD-ME in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, ELISA, IF and IHC (p).

Quick Overview for NAD-ME antibody (AA 26-584) (ABIN7873011)

Target: NAD-ME (NAD Dependent Malate Dehydrogenase (NAD-ME))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAD-ME antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NAD-ME Antibody

Binding Specificity: AA 26-584

Purpose: ME2 Antibody / NAD-ME

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids K26-E584) was used as the immunogen for the ME2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ME2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ME2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NAD-ME

Target: NAD-ME (NAD Dependent Malate Dehydrogenase (NAD-ME))

Alternative Name: ME2

Background: NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene. It is mapped to 18q21.2. This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.

UniProt: P23368

Pathways: Production of Molecular Mediator of Immune Response