SUN1 antibody (AA 32-619)

Catalog No. ABIN7873935

The Rabbit Polyclonal anti-SUN1 antibody is suitable to detect SUN1 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for SUN1 antibody (AA 32-619) (ABIN7873935)

Target: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-SUN1 Antibody

Binding Specificity: AA 32-619

Purpose: SUN1 Antibody / Sad1/UNC-84 domain-containing protein 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SUN1 recombinant protein (Position: D32-E619) was used as the immunogen for the SUN1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SUN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SUN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SUN1

Target: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Alternative Name: SUN1

Background: SUN1 antibody detects Sad1/UNC-84 domain-containing protein 1, encoded by the SUN1 gene on chromosome 7p22.3. SUN1 antibody is widely used in nuclear envelope, cytoskeletal, and cell structure research. SUN1 is an inner nuclear membrane protein that interacts with KASH domain proteins at the outer nuclear membrane to form the LINC (linker of nucleoskeleton and cytoskeleton) complex. This complex physically connects the nuclear interior with the cytoskeleton, enabling nuclear positioning, mechanotransduction, and chromosome dynamics.

Structurally, SUN1 is a ~90 kDa type II transmembrane protein with a conserved SUN domain that extends into the perinuclear space. It anchors to the nuclear lamina and interacts with chromatin-associated proteins inside the nucleus. SUN1 can heterodimerize with SUN2 to form diverse LINC complexes. Expression is ubiquitous, with enrichment in proliferating and differentiating cells.

Functionally, SUN1 regulates nuclear migration, anchorage, and mechanotransduction. It is essential for meiotic chromosome pairing, telomere tethering, and centrosome-nucleus coupling. SUN1 also contributes to DNA repair and genomic stability. Researchers use SUN1 antibody to study nuclear organization, mechanobiology, and chromosome dynamics.

Clinically, SUN1 mutations and dysregulation are associated with laminopathies, muscular dystrophies, and neurodevelopmental disorders. Disruption of the LINC complex impairs nuclear positioning and mechanosignaling, leading to disease. SUN1 also contributes to cancer progression by altering nuclear morphology and chromatin organization. NSJ Bioreagents provides SUN1 antibody for research in nuclear architecture, mechanobiology, and disease mechanisms.

Experimentally, SUN1 antibody is used in western blotting to detect the ~90 kDa protein, in immunofluorescence microscopy to visualize nuclear envelope localization, and in immunohistochemistry to study tissue-specific expression. Co-immunoprecipitation with SUN1 antibody identifies binding partners within the LINC complex.

UniProt: O94901

Pathways: Maintenance of Protein Location