ChT antibody (AA 446-580)

Catalog No. ABIN7875049

The Rabbit Polyclonal anti-ChT antibody (ABIN7875049) specifically detects ChT in WB, FACS and ELISA. The antibody is reactive with Mouse, Human and Rat samples.

Quick Overview for ChT antibody (AA 446-580) (ABIN7875049)

Target: ChT (High Affinity Choline Transporter (ChT))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ChT antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Product Details anti-ChT Antibody

Binding Specificity: AA 446-580

Purpose: SLC5A7 Antibody / High affinity choline transporter 1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R446-Q580) was used as the immunogen for the SLC5A7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SLC5A7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SLC5A7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ChT

Target: ChT (High Affinity Choline Transporter (ChT))

Alternative Name: SLC5A7

Background: The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. This gene encodes a sodium ion- and chloride ion-dependent high-affinity transporter that mediates choline uptake for acetylcholine synthesis in cholinergic neurons. The protein transports choline from the extracellular space into presynaptic terminals for synthesis into acetylcholine. Increased choline uptake results from increased density of this protein in synaptosomal plasma membranes in response to depolarization of cholinergic terminals. Dysfunction of cholinergic signaling has been implicated in various disorders including depression, attention-deficit disorder, and schizophrenia. An allelic variant of this gene is associated with autosomal dominant distal hereditary motor neuronopathy type VIIA. Alternative splicing results in multiple transcript variants.

UniProt: Q9GZV3