SMC1A antibody (AA 59-1233)

Catalog No. ABIN7875873

The Rabbit Polyclonal anti-SMC1A antibody is suitable to detect SMC1A in samples from Human. It has been validated for WB, ELISA and IF.

Quick Overview for SMC1A antibody (AA 59-1233) (ABIN7875873)

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-SMC1A Antibody

Binding Specificity: AA 59-1233

Purpose: SMC1A Antibody / Structural maintenance of chromosomes protein 1A

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids K59-Q1233) was used as the immunogen for the SMC1A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SMC1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SMC1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Alternative Name: SMC1A

Background: Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q14683

Pathways: Stem Cell Maintenance