Recombinant CD5 antibody (full length)

Catalog No. ABIN7877920

The Rabbit Monoclonal anti-CD5 antibody (Clone C5-6438R) (ABIN7877920) specifically detects CD5 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant CD5 antibody (full length) (ABIN7877920)

Target: CD5

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD5 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: C5-6438R

Product Details anti-CD5 Antibody

Binding Specificity: full length

Purpose: Recombinant CD5 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length protein was used as the immunogen for the recombinant CD5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant CD5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant CD5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD5

Target: CD5

Alternative Name: CD5

Background: The CD5 antigen is a transmembrane glycoprotein expressed on the surface of practically all mature human T-cells (about 10 % of CD4+ T-cells being CD5 negative). In immature (CD34+) T-cells, CD5 is weakly expressed, the intensity of expression increasing with maturation. CD5 is also expressed in a small subset of normal human B-cells (20 % of B-cells in the peripheral blood, scattered cells in the lymph node mantle zone). The CD5+ cells are probably involved in B-T interaction and their ligand is CD72 which is expressed on all B cells. It appears that CD5+ B-cells on activation primarily produce IgM. They also produce more autoantibodies than normal CD5 negative B-cells. Thus, the CD5+ B-cell population is expanded in rheumatoid arthritis and systemic lupus erythematosus. The CD5 antibody reacts with CD5 expressed on B and T cells, and may be a useful aid for the classification of B and T-cell malignancies. This includes B-cell chronic lymphoid leukemia (B-CLL), B-cell small lymphocytic lymphoma (B-SLL), mantle cell lymphoma (MCL) and T-cell lymphoma and leukemia.

UniProt: P06127