Recombinant CD8 alpha antibody (full length)

Catalog No. ABIN7877959

The Rabbit Monoclonal anti-CD8 alpha antibody (Clone CD8-7793R) (ABIN7877959) specifically detects CD8 alpha in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant CD8 alpha antibody (full length) (ABIN7877959)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CD8-7793R

Product Details anti-CD8 alpha Antibody

Binding Specificity: full length

Purpose: CD8A Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length CD8a protein was used as the immunogen for the CD8A antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the CD8A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CD8A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8A

Background: This mAb is specific for the 32 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

UniProt: P01732

Pathways: TCR Signaling