Recombinant Chromogranin A antibody (full length)

Catalog No. ABIN7877980

The Mouse Monoclonal anti-Chromogranin A antibody (Clone rCHGA-798) (ABIN7877980) specifically detects Chromogranin A in IHC (p). The antibody is reactive with Human and Rat samples.

Quick Overview for Recombinant Chromogranin A antibody (full length) (ABIN7877980)

Target: Chromogranin A (CHGA)

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Chromogranin A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RCHGA-798

Product Details anti-Chromogranin A Antibody

Binding Specificity: full length

Purpose: Recombinant Chromogranin A Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for the recombinant Chromogranin A antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Chromogranin A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant Chromogranin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Chromogranin A

Target: Chromogranin A (CHGA)

Alternative Name: Chromogranin A

Background: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling