CD83 antibody (N-Term)

Catalog No. ABIN7879584

The Mouse Monoclonal anti-CD83 antibody is suitable to detect CD83 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for CD83 antibody (N-Term) (ABIN7879584)

Target: CD83

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD83 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1H4b

Product Details anti-CD83 Antibody

Binding Specificity: N-Term

Purpose: CD83 Antibody

Purification: Protein G affinity

Immunogen: Prokaryotic recombinant protein corresponding to 124 amino acids of the external N-terminus of the CD83 molecule was used as the immunogen for the CD83 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD83 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD83 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD83

Target: CD83

Alternative Name: CD83

Background: CD83 is a heavily glycosylated membrane protein of the immunoglobulin (Ig) superfamily that is expressed in mature Dendritic cells, Langerhans cells and interdigitating reticulum cells within lymphoid tissues. Structurally, CD83 resembles other Ig superfamily members, which have an extracellular V-type Ig-like domain, a single transmembrane domain and a 40 residue cytoplasmic tail. CD83 expression is used as a marker for mature, antigen presenting Dendritic cells that are capable of generating tumor-specific T cell immunity, a phenotype with implications as an anti-cancer vaccine. CD83-IgG1(Fc) chimera studies indicate that CD83 is a sialic acid-binding, Ig-like Lectin (Siglec) adhesion molecule that is involved in cell adhesion/signaling by hosting Dendritic cell interactions with monocytes and CD8+ T cells.

UniProt: Q01151