Recombinant MLANA antibody (N-Term)

Catalog No. ABIN7879617

The Rabbit Monoclonal anti-MLANA antibody is suitable to detect MLANA in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant MLANA antibody (N-Term) (ABIN7879617)

Target: MLANA (Melan A (MLANA))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MLANA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MLANA-8365R

Product Details anti-MLANA Antibody

Binding Specificity: N-Term

Purpose: Melan-A Antibody / MART-1

Purification: Protein A/G affinity

Immunogen: A recombinant fragment corresponding to the N-terminus of human Melan A protein was used as the immunogen for the Melan-A antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Melan-A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Melan-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MLANA

Target: MLANA (Melan A (MLANA))

Alternative Name: Melan-A

Background: This antibody recognizes a protein doublet of 20-22 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This mAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

UniProt: Q16655