Recombinant CD147 antibody

Catalog No. ABIN7880053

The Rabbit Monoclonal anti-CD147 antibody (Clone 30B80) (ABIN7880053) specifically detects CD147 in WB, IHC, IF, IP and ICC. The antibody is reactive with Mouse samples.

Quick Overview for Recombinant CD147 antibody (ABIN7880053)

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD147 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: 30B80

Product Details anti-CD147 Antibody

Purpose: Bsg Antibody / CD147

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CD147 was used as the immunogen for the Bsg antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Bsg antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Bsg antibody at -20oC.

Target Details for CD147

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Alternative Name: Bsg

Background: BSG antibody detects basigin, also known as CD147, an immunoglobulin superfamily member encoded by the BSG gene. Basigin is a transmembrane glycoprotein expressed in many tissues and cell types. It functions as a receptor and regulator of matrix metalloproteinases, monocarboxylate transporters, and extracellular signaling molecules. By modulating these pathways, basigin influences immune responses, metabolism, and tumor progression.

BSG antibody is widely used in immunology, oncology, and infectious disease research. In cancer, basigin promotes tumor invasion and metastasis by inducing matrix metalloproteinase activity. It also regulates metabolic processes by facilitating lactate transport through interactions with monocarboxylate transporters. By detecting basigin, researchers can study how CD147 contributes to the tumor microenvironment and cellular metabolism.

The antibody is suitable for western blotting, flow cytometry, immunohistochemistry, and immunofluorescence. In western blot assays, BSG antibody detects protein bands corresponding to basigin in multiple tissues. Flow cytometry enables quantitative assessment of CD147 expression on immune and tumor cells. Immunohistochemistry reveals tissue specific patterns, while immunofluorescence highlights subcellular localization at plasma membranes.

Basigin also plays roles in immunity and infectious disease. It regulates leukocyte activation, T cell function, and pathogen interactions. Basigin has been identified as a receptor for certain parasites and viruses, linking it to infectious disease research. By using BSG antibody, scientists can evaluate the role of CD147 in host pathogen interactions and immune regulation.

BSG antibody from NSJ Bioreagents provides strong specificity for detecting basigin in cancer, immunity, and metabolism. Its proven reliability across techniques ensures accurate results for both basic and translational studies.

UniProt: P18572

Pathways: S100 Proteins