GRID2 antibody

Catalog No. ABIN7880884

The Rabbit Polyclonal anti-GRID2 antibody (ABIN7880884) specifically detects GRID2 in WB, FACS and IHC (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for GRID2 antibody (ABIN7880884)

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRID2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GRID2 Antibody

Purpose: GRID2 Antibody

Sequence: KKDDEVFRTA VGDLNQN

Purification: Affinity purified

Immunogen: Amino acids KKDDEVFRTAVGDLNQN from the human protein were used as the immunogen for the GRID2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GRID2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GRID2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GRID2

Target: GRID2 (Glutamate Receptor, Ionotropic, delta 2 (GRID2))

Alternative Name: GRID2

Background: Glutamate receptor, ionotropic, delta 2, also known as GluD2 and GluR delta 2, is a protein that in humans is encoded by the GRID2 gene. The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

UniProt: O43424

Pathways: Synaptic Membrane