Recombinant MYH2 antibody

Catalog No. ABIN7881734

The Rabbit Monoclonal anti-MYH2 antibody (Clone 32M67) (ABIN7881734) specifically detects MYH2 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant MYH2 antibody (ABIN7881734)

Target: MYH2 (Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MYH2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 32M67

Product Details anti-MYH2 Antibody

Purpose: MYH2 Antibody / Myosin heavy chain 2

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human MYH2 was used as the immunogen for the MYH2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MYH2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the MYH2 antibody at -20oC.

Target Details for MYH2

Target: MYH2 (Myosin Heavy Chain 2, Skeletal Muscle, Adult (MYH2))

Alternative Name: MYH2

Background: MYH2 antibody detects myosin heavy chain 2, encoded by the MYH2 gene. MYH2 is a skeletal muscle myosin isoform expressed in type IIa fast oxidative fibers. Myosin heavy chains are motor proteins that convert ATP hydrolysis into mechanical force, driving actin-based muscle contraction. MYH2 provides intermediate contractile velocity and fatigue resistance, making it a key determinant of muscle performance.

MYH2 antibody is widely applied in muscle physiology, pathology, and developmental biology research. Detection of MYH2 expression distinguishes type IIa fibers from other fiber types, supporting studies of muscle composition and plasticity. In clinical research, MYH2 expression patterns are examined in muscular dystrophy, myopathies, and age-related sarcopenia. By detecting MYH2, researchers can assess muscle adaptation to exercise, disease, and therapeutic interventions.

Western blot assays detect MYH2 protein in skeletal muscle extracts. Immunohistochemistry maps MYH2 distribution within muscle cross sections, enabling identification of fiber type composition. Immunofluorescence highlights sarcomeric localization, providing high-resolution visualization of contractile architecture.

MYH2 mutations cause autosomal dominant myopathy characterized by progressive muscle weakness, abnormal fiber morphology, and impaired contractility. Detection with MYH2 antibody supports genetic and pathological studies of this disease. Additionally, MYH2 is a marker of regenerative fibers and is used to study developmental myogenesis. By applying MYH2 antibody, scientists can investigate both physiological and pathological aspects of skeletal muscle biology.

Beyond skeletal muscle, MYH2 research contributes to understanding of biomechanics, metabolic regulation, and aging. Differences in MYH2 expression across individuals and conditions reflect muscle plasticity and adaptation. The antibody therefore provides a critical reagent for both basic science and translational studies in muscle biology.

MYH2 antibody from NSJ Bioreagents offers dependable specificity for detecting type IIa myosin heavy chain, supporting high-quality studies of skeletal muscle physiology and disease.

UniProt: Q9UKX2