TSHB antibody

Catalog No. ABIN7882486

The Mouse Monoclonal anti-TSHB antibody is suitable to detect TSHB in samples from Human. It has been validated for IHC (p).

Quick Overview for TSHB antibody (ABIN7882486)

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TSHB antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TSHb-1317

Product Details anti-TSHB Antibody

Purpose: TSHB Antibody / TSH beta

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein was used as the immunogen for this TSHB antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the TSHB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the TSHB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TSHB

Target: TSHB (Thyroid Stimulating Hormone, beta (TSHB))

Alternative Name: TSHB

Background: The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH) follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated non-covalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. TSH is synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. TSH stimulates the thyroid gland to secrete the hormones thyroxine (T4) and triiodothyronine (T3). TSH production is controlled by a Thyrotropin-Releasing Hormone (TRH), which is manufactured in the hypothalamus and transported to the pituitary gland, where it increases TSH production and release. Somatostatin is also produced by the hypothalamus and has an opposite effect on the pituitary production of TSH, decreasing or inhibiting its release. TSH is a useful marker in classification of pituitary tumors and the study of pituitary disease.

UniProt: P01222

Pathways: Thyroid Hormone Synthesis, Peptide Hormone Metabolism