CRLF2 antibody (AA 81-180) (Biotin)

Catalog No. ABIN749740

This Rabbit Polyclonal antibody specifically detects CRLF2 in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CRLF2 antibody (AA 81-180) (Biotin) (ABIN749740)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRLF2 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CRLF2 Antibody (Biotin)

Binding Specificity: AA 81-180

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CRLF2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Alternative Name: Crlf2

Background:

Synonyms: TSLPR, CRLF2, CRL 2, CRL2, CRLF 2, CRLF2Y, Cytokine receptor CRL2 precusor, Cytokine receptor like 2, Cytokine receptor like factor 2, Cytokine receptor like factor 2 precursor, IL XR, ILXR, Thymic stromal derived lymphopoietin receptor, Thymic stromal lymphopoietin protein receptor, Thymic stromal lymphopoietin receptor, TSLP receptor, TSLPR.

Background: TSLPR is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP. The TSLP R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLPR has a predicted molecular weight approximately 41 kD, and two further isoforms have been reported that are produced by alternative splicing. The TSLPR is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases.

Gene ID: 64109