RORC antibody

Catalog No. ABIN750298

This Rabbit Polyclonal antibody specifically detects RORC in WB, IHC (p) and IF (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RORC antibody (ABIN750298)

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RORC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RORC Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ROR Gamma

Isotype: IgG

Application Details

Application Notes: WB: (1:100-1000), IHC-P: (1:100-500), IF(IHC-P): (1:50-200)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for RORC

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Alternative Name: Ror gamma/rorc

Background:

Synonyms: NR1F3, Nuclear receptor ROR gamma, Nuclear receptor ROR-gamma, Nuclear receptor RZR gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RAR related orphan receptor C, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, Retinoic acid binding receptor gamma, Retinoid related orphan receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, RORG, RZR GAMMA, RZRG, TOR.

Background: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known, however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Gene ID: 6097

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway