PKA Regulatory Subunit I beta (AA 5-100) antibody

Catalog No. ABIN751828

This Rabbit Polyclonal antibody specifically detects PKA Regulatory Subunit I beta in ELISA, IF (cc), IF (p), IHC (fro), IHC (p) and WB. It exhibits reactivity toward Human.

Quick Overview for PKA Regulatory Subunit I beta (AA 5-100) antibody (ABIN751828)

Target: PKA Regulatory Subunit I beta

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Product Details

Binding Specificity: AA 5-100

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PKA regulatory subunit I beta

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: PKA Regulatory Subunit I beta

Background:

Synonyms: cAMP dependent protein kinase type I beta regulatory subunit, PKARI beta, PRKAR 1, PRKAR 1B, PRKAR1, PRKAR1B, PRKAR1B protein, Protein kinase cAMP dependent regulatory type I beta, RI beta, KAPCB_HUMAN.

Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2011].

Gene ID: 5575