APP antibody (pSer730) (FITC)

Catalog No. ABIN755849

The Rabbit Polyclonal anti-APP antibody has been validated for FACS, IF (cc) and IF (p). It is suitable to detect APP in samples from Mouse and Rat.

Quick Overview for APP antibody (pSer730) (FITC) (ABIN755849)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-APP Antibody (FITC)

Binding Specificity: pSer730

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human APP770 around the phosphorylation site of Ser730

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: Amyloid Precursor Protein

Background:

Synonyms: Amyloid Precursor Protein phospho S730, Amyloid Precursor Protein phospho Ser730, p-Amyloid Precursor Protein phospho S730, APP Ser730, p-APPSer730, C31, C80, C83, C99, beta-amyloid precursor protein C-terminus, A4 amyloid protein, A4, AAA, ABETA, ABPP, AD 1, AD1, Alzheimer disease 1, Alzheimer disease, Alzheimer's disease amyloid protein, Amyloid beta A4 precursor protein, Amyloid beta A4 protein, Amyloid beta A4 protein precursor isoform b, Amyloid beta A4 protein precursor isoform c, Amyloid beta A4 protein precursor isoform a, Amyloid beta A4 protein precursor isoform b, Amyloid beta A4 protein precursor isoform c, Amyloid beta protein, Amyloid beta-peptide, Amyloid of aging and alzheimer disease, APP, APP I , APPI, Beta amyloid peptide, Cerebral vascular amyloid peptide, CTFgamma, CVAP, Human mRNA for amyloid A4 precursor of Alzheimer's disease, PN 2, PN II, PN2, PreA4, Protease nexin II, A4_HUMAN.

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Gene ID: 351

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour