PCDHGB5 antibody (AA 21-120)

Catalog No. ABIN758471

The Rabbit Polyclonal anti-PCDHGB5 antibody has been validated for WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) and ICC. It is suitable to detect PCDHGB5 in samples from Human.

Quick Overview for PCDHGB5 antibody (AA 21-120) (ABIN758471)

Target: PCDHGB5 (Protocadherin gamma Subfamily B, 5 (PCDHGB5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGB5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-PCDHGB5 Antibody

Binding Specificity: AA 21-120

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PCDHGB5

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PCDHGB5

Target: PCDHGB5 (Protocadherin gamma Subfamily B, 5 (PCDHGB5))

Alternative Name: PCDHGB5

Background:

Synonyms: PCDH gamma B5, PCDHGB 5, Protocadherin gamma B5, Protocadherin gamma subfamily B 5, PCDGH_HUMAN.

Background: PCDHGB5 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.