AIMP1 antibody (AA 201-300) (HRP)

Catalog No. ABIN759665

The Rabbit Polyclonal anti-AIMP1 antibody has been validated for WB, ELISA, IHC (p) and IHC (fro). It is suitable to detect AIMP1 in samples from Human.

Quick Overview for AIMP1 antibody (AA 201-300) (HRP) (ABIN759665)

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AIMP1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-AIMP1 Antibody (HRP)

Binding Specificity: AA 201-300

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EMAP2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AIMP1

Target: AIMP1 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 1 (AIMP1))

Alternative Name: EMAP2

Background:

Synonyms: AIMP 1, Aimp1, AIMP1/p43, AIMP1_HUMAN , Aminoacyl tRNA synthetase complex-interacting multunctional protein 1, ARS interacting multunctional protein 1, ARS-interacting multunctional protein 1, EMAP 2, EMAP-2, EMAP-II, EMAP II, EMAP2, EMAPII, Endothelial monocyte activating polypeptide 2, Endothelial Monocyte Activating Polypeptide, Endothelial monocyte-activating polypeptide 2, Endothelial monocyte-activating polypeptide II, Multisynthase complex auxiliary component p43, Multisynthetase complex auxiliary component p43, p43 antibody Scye 1, Scye1, Small Inducible Cytokine Subfamily E Member 1, Small inducible cytokine subfamily E, member 1 endothelial monocyte-activating.

Background: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.

Gene ID: 9255