CPEB1 antibody (AA 451-550) (Cy3)

Catalog No. ABIN761504

The Rabbit Polyclonal anti-CPEB1 antibody has been validated for WB, IF (cc) and IF (p). It is suitable to detect CPEB1 in samples from Human.

Quick Overview for CPEB1 antibody (AA 451-550) (Cy3) (ABIN761504)

Target: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CPEB1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CPEB1 Antibody (Cy3)

Binding Specificity: AA 451-550

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CPEB1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CPEB1

Target: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Alternative Name: CPEB1

Background:

Synonyms: CPE-binding protein 1, CPE-BP1, CPEB 1, CPEB, CPEB1, CPEB1 protein, CPEB1_HUMAN, Cytoplasmic polyadenylation binding protein 1, Cytoplasmic polyadenylation element binding protein, Cytoplasmic polyadenylation element binding protein 1, Cytoplasmic polyadenylation element-binding protein 1, h-CEBP, hCPEB-1

Background: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.

Gene ID: 64506

Pathways: Synaptic Membrane