CR1L antibody

Catalog No. ABIN781721

Product Details anti-CR1L Antibody

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CR1L antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Specificity: This antibody detects Crry. The antigen is found on numerous cells in blood and various tissues.

Cross-Reactivity (Details): Species reactivity (tested):Rat

Purification: Affinity chromatography

Immunogen: Erythrocytes from a C3 mutated rat

Clone: 512

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Reconstitute by adding 0.5 mL distilled water.

Buffer: Stock solution contains 0.4 mg/mL IgG, phosphate buffered saline pH 7.2 (PBS), 5 mg/mL bovine serum albumin (BSA) as a stabilizer and 0.09 % sodium azide as a preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

Target Details for CR1L

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Alternative Name: CR1L / CRRY (CR1L Products)

Synonyms: CREG antibody, Cr1 antibody, Crry antibody, Mcp antibody, mCRY antibody, complement C3b/C4b receptor 1 like antibody, complement component (3b/4b) receptor 1-like antibody, CR1L antibody, Cr1l antibody

Background: Crry is a cofactor for complement factor I. Crry seems to act as a costimulatory factor for T-cells and is expressed on different tissues, particularly also on thymocytes and non-lymphoid cells in the thymus. Crry may play an important role in the early embryonic development by maintaining fetomaternal tolerance. Two forms of Crry exist, containing six or seven extracellular short consensus repeats (SCRs), respectively, plus a transmembrane and a cytoplasmic domain. The molecular weights of the native glycoproteins are approximately 55 and 65 kDa, respectively.Synonyms: Antigen 5I2, Complement component receptor 1-like protein, Complement regulatory protein Crry

Gene ID: 54243

NCBI Accession: NP_001005265

UniProt: Q63135

Pathways: Complement System