VAMP1 antibody

Catalog No. ABIN782443

This Mouse Monoclonal antibody specifically detects VAMP1 in WB and IHC (fro). It exhibits reactivity toward Human, Rat, Mouse, Cow, Rabbit, Pig and Hamster.

Quick Overview for VAMP1 antibody (ABIN782443)

Target: VAMP1 (Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) (VAMP1))

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Pig, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This VAMP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: SP10

Product Details anti-VAMP1 Antibody

Specificity: The antibody is specific for the ~16 kDa synaptobrevin protein in Western blots of rat brain lysate.

Cross-Reactivity (Details): Species reactivity (tested):Human, Pig, Hamster, Rat, Rabbit, Mouse, and Bovine.
Also reacts to: VAMP2

Purification: Affinity Chromatography.

Immunogen: Synaptic immunoprecipitate (crude) from Human brain.

Isotype: IgM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C.

Target Details for VAMP1

Target: VAMP1 (Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) (VAMP1))

Alternative Name: VAMP-1 / Synaptobrevin-1

Background: Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive defects in Alzheimer's disease (Sze et al., 2000).Synonyms: SYB1, VAMP1, Vesicle-associated membrane protein 1

Gene ID: 6843

NCBI Accession: NP_055046

UniProt: P23763