CR1L antibody

Catalog No. ABIN782451

Product Details anti-CR1L Antibody

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CR1L antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Specificity: Purified Anti-Rat Crry monoclonal antibody (Clone: 5I2) is a rat-specific membrane complement regulator that can inhibit both antibody-induced classical pathway and alternative pathway complement activation. Crry plays a more dominant role than DAF in regulating the alternative pathway of complement and in preventing spontaneous complement damage of rat erythrocytes, whereas DAF and Crry are both expressed and are equally effective in preventing antibody-induced runaway complement activation on rat erythrocytes.

Purification: Affinity chromatography on Protein G

Immunogen: Erythrocytes from a C3 mutated rat

Clone: 512

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide (NaN3) as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CR1L

Target: CR1L (Complement Component (3b/4b) Receptor 1-Like (CR1L))

Alternative Name: CR1L / CRRY (CR1L Products)

Background: Synonyms: Antigen 5I2, Complement component receptor 1-like protein, Complement regulatory protein Crry

Gene ID: 54243

NCBI Accession: NP_001005265

UniProt: Q63135

Pathways: Complement System