ZBTB5 antibody (C-Term)

Catalog No. ABIN783357

This anti-ZBTB5 antibody is a Rabbit Polyclonal antibody detecting ZBTB5 in WB and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for ZBTB5 antibody (C-Term) (ABIN783357)

Target: ZBTB5 (Zinc Finger and BTB Domain Containing 5 (ZBTB5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB5 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ZBTB5 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects ZBTB5 at C-term. At least two isoforms of ZBTB5 are known to exist, this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the carboxy terminus of human ZBTB6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ZBTB5

Target: ZBTB5 (Zinc Finger and BTB Domain Containing 5 (ZBTB5))

Alternative Name: ZBTB5

Background: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene.Synonyms: KIAA0354, Zinc finger and BTB domain-containing protein 5

Gene ID: 9925

NCBI Accession: NP_055687

UniProt: O15062