AXIN2 antibody (C-Term)

Catalog No. ABIN783373

This Rabbit Polyclonal antibody specifically detects AXIN2 in WB and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for AXIN2 antibody (C-Term) (ABIN783373)

Target: AXIN2 (Axin 2 (AXIN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXIN2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-AXIN2 Antibody

Binding Specificity: C-Term

Specificity: Thias antibody detects Axin-2 at C-term. It is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist, this antibody will recognize all four.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 20 amino acid peptide near the carboxy terminus of human AXIN2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Alternative Name: Axin-2

Background: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.Synonyms: AXIN2, Axin-like protein, Axis inhibition protein 2, Conductin

Gene ID: 8313

NCBI Accession: NP_004646

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling