LRRTM3 antibody (C-Term)

Catalog No. ABIN783383

The Rabbit Polyclonal anti-LRRTM3 antibody is suitable to detect LRRTM3 in samples from Mouse, Human and Rat. It has been validated for WB and EIA.

Quick Overview for LRRTM3 antibody (C-Term) (ABIN783383)

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRTM3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-LRRTM3 Antibody

Binding Specificity: C-Term

Specificity: This antibnody detects LRRTM3 at C-term. At least two isoforms of LRRTM3 are known to exist, this antibody will only detect the larger isoform.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human LRRTM3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for LRRTM3

Target: LRRTM3 (Leucine Rich Repeat Transmembrane Neuronal 3 (LRRTM3))

Alternative Name: LRRTM3

Background: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the β-secretase BACE, leading to the proteolytic production of the Aβ42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Aβ42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.Synonyms: Leucine-rich repeat transmembrane neuronal protein 3

Gene ID: 26045

NCBI Accession: NP_056379

UniProt: Q86VH5

Pathways: Synaptic Membrane