HMMR antibody (N-Term)

Catalog No. ABIN783397

This Rabbit Polyclonal antibody specifically detects HMMR in WB and EIA. It exhibits reactivity toward Human, Mouse and Ratand has been mentioned in 1 publication.

Quick Overview for HMMR antibody (N-Term) (ABIN783397)

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HMMR antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-HMMR Antibody

Binding Specificity: N-Term

Specificity: This antibody detects CD168 / HMMR at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of human RHAMM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

References for anti-HMMR antibody (ABIN783397)

Li, Ji, Wang: "Targeting Long Noncoding RNA HMMR-AS1 Suppresses and Radiosensitizes Glioblastoma." in: Neoplasia (New York, N.Y.), Vol. 20, Issue 5, pp. 456-466, (2018) (PubMed).

Target Details for HMMR

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Alternative Name: CD168 / HMMR

Background: The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.Synonyms: Hyaluronan mediated motility receptor, IHABP, Intracellular hyaluronic acid-binding protein, RHAMM, Receptor for hyaluronan-mediated motility

Gene ID: 3161

NCBI Accession: NP_001136028

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process