CCDC141 antibody (N-Term)

Catalog No. ABIN783520

This Rabbit Polyclonal antibody specifically detects CCDC141 in WB and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for CCDC141 antibody (N-Term) (ABIN783520)

Target: CCDC141 (Coiled-Coil Domain Containing 141 (CCDC141))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC141 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CCDC141 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects CCDC141 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the amino terminus of human CCDC141

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for CCDC141

Target: CCDC141 (Coiled-Coil Domain Containing 141 (CCDC141))

Alternative Name: CCDC141

Background: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development. At least four isoforms of CCDC141 are known to exist.Synonyms: Coiled-coil domain-containing protein 141

Gene ID: 285025

NCBI Accession: NP_775919

UniProt: Q6ZP82