SP110 antibody (N-Term)

Catalog No. ABIN783560

The Rabbit Polyclonal anti-SP110 antibody has been validated for WB and EIA. It is suitable to detect SP110 in samples from Human, Mouse and Rat.

Quick Overview for SP110 antibody (N-Term) (ABIN783560)

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP110 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SP110 Antibody

Binding Specificity: N-Term

Specificity: This antibody detects SP110 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of the human IPR1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for SP110

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Alternative Name: SP110

Background: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.Synonyms: FLJ22835, IPR1, SP-110, SP110 nuclear body protein, Speckled 110 kD, VODI

Gene ID: 3431

NCBI Accession: NP_001171944

UniProt: Q9HB58